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📚 Literature review

Write a literature review (last 5 years) on the role of TF12 (GATA family) in nitrogen limitation response in Chlamydomonas reinhardtii. List the leading hypotheses and the points of disagreement.

🧪 Experiment design

Design a set of characterization experiments for TF12 in C. reinhardtii aimed at a Science paper, covering structural biology, multi-omics time courses, and synthetic biology validation.

⚗️ Retrosynthesis

Starting from aspirin (CC(=O)Oc1ccccc1C(=O)O), design a 4-step retrosynthesis route to (R)-thalidomide. Give a yield estimate for each step.

🧬 Omics analysis

For a nitrogen-starvation RNA-seq time course in C. reinhardtii (0/2/6/24/72h, n=3), recommend an analysis pipeline and predict likely differentially-expressed hub genes.